Article

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

2021-02-10

Abstract excerpt

Oncogenic KRAS mutations are considered to be a key driver for initiation and progression in non-small-cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity and downstream signals remain largely unclear. Here, we showed that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with KRAS and methylates KRAS at lysin...

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Literature Corpus work: d6654a36-f83a-53cd-a335-1e90acc35121
DOI: 10.1101/2021.02.10.429309

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