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Article

Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer.

Nature chemical biology - 1 Jan 2025

Peng Zhiqiang, Fang Wei, Wu Bo, He Ming, Li Shaohua, Wei Jun, Hao Yang, Jin Lujia, Liu Mingqiu, Zhang Xin, Wei Yange, Ge Yingwei, Wei Yinghua, Qian Haili, Zhang Yangjun, Jiang Junyi, Chang Zhijie, Rao Yu, Zhang Xueli, Cui Chun-Ping, Zhang Lingqiang

Abstract excerpt

The phosphoinositide 3-kinase (PI3K)-Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC). Targeting the PI3K-Akt pathway has been a challenging undertaking through the decades. Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39039255
DOI: 10.1038/s41589-024-01683-5

Genes

PDK1
KRAS
SETDB1
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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