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Article

SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.

Oncotarget - 6 Dec 2016

Song Ha Yong, Biancucci Marco, Kang Hong-Jun, O'Callaghan Carol, Park Seong-Hoon, Principe Daniel R, Jiang Haiyan, Yan Yufan, Satchell Karla Fullner, Raparia Kirtee, Gius David, Vassilopoulos Athanassios

Abstract excerpt

The observation that cellular transformation depends on breaching a crucial KRAS activity threshold, along with the finding that only a small percentage of cellsharboring KRAS mutations are transformed, support the idea that additional, not fully uncovered, regulatory mechanisms may contribute to KRAS activation. Here we report that KrasG12D mice lacking Sirt2 show an aggressive tumorigenic phenotype as compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27637077
DOI: 10.18632/oncotarget.12015
PMCID: PMC5340253

Genes

KRAS
SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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