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Article

USP7 deubiquitinates KRAS and promotes non-small cell lung cancer.

Cell reports - 26 Nov 2024

Huang Bin, Cao Dan, Yuan Xiao, Xiong Yuxian, Chen Bingzhang, Wang Yingjie, Niu Xiaogang, Tian Ruijun, Huang Hao

Abstract excerpt

RAS oncogenic mutations are pivotal drivers of tumorigenesis. Ubiquitination modulates RAS functions, including activation, stability, and localization. While several E3 ligases regulate RAS ubiquitination, RAS deubiquitination remains less understood. Our study reveals that ubiquitin-specific protease 7 (USP7) directly deubiquitinates KRAS, stabilizing it and promoting the proliferation of non-small cell lung...

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PMID: 39499616
DOI: 10.1016/j.celrep.2024.114917

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