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Article

The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma.

Cancer research communications - 1 Jan 2026

Shaheen Menna-T-Allah, Dhebat Sarah, Rajapakshe Kimal I, Ghosh Bidyut, Chellakkan Selvanesan Benson, Ansari Shariq S, Haymaker Cara L, Sadeghian Dorsay, Wang Huamin, Li Ching-Fei, Ying Haoqiang, Maitra Anirban

Abstract excerpt

Deregulation of proteins involved in chromatin regulation is common in pancreatic ductal adenocarcinoma (PDAC). Lysine demethylase 4C (KDM4C) is one of the chromatin-modifying proteins frequently overexpressed across multiple solid cancers and is linked to chromatin instability, increased cell proliferation, and enhanced stem cell-like behavior. We observed upregulation of KDM4C protein in a panel of human PDAC...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to Jumonji Domain-Containing Histone Demethylases

Share to MAP Kinase Signaling System

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 41490602
DOI: 10.1158/2767-9764.CRC-25-0278
PMCID: PMC12856980

Genes

KDM4C
KRAS
SIRT1
DUSP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma.PMID 41490602Read ↗

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