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Article

LKB1 Loss Upregulates ALKBH5 and Contributes to Aggressive Phenotypes of KRAS Mutated Lung Cancer

2020-11-18

Abstract excerpt

<h4>Background: </h4> Oncogenic KRAS mutations combined with loss of the LKB1 tumor-suppressor gene (KL) are strongly associated with aggressive forms of lung cancer. N6-methyladenosine (m6A) in mRNA is a crucial epigenetic modification that controls cancer self-renewal and progression. However, the function, regulation and mechanism of m6A in this aggressive phenotypes remain largely unclear. <h4>Methods: </h4>:...

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Literature Corpus work
1856d2a6-7437-5fe3-bd10-a47f336aca18
DOI
10.21203/rs.3.rs-105982/v1
Open publication

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LKB1 Loss Upregulates ALKBH5 and Contributes to Aggressive Phenotypes of KRAS Mutated Lung CancerDOI 10.21203/rs.3.rs-105982/v1
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