Article

Characterization of the motor cortex transcriptome supports microgial-related key events in amyotrophic lateral sclerosis

2020-02-07

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of upper and lower motor neurons. A major neuropathological finding in ALS is the coexistence of glial activation and aggregation of the phosphorylated transactive response DNA-binding protein 43-kDa (pTDP43) in the motor cortex at the earliest stages of the disease. Despite this, the transcriptional al...

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Literature Corpus work: 112296da-3bcb-5130-ac6f-45f8fd80c440
DOI: 10.1101/2020.02.07.938662

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