Article

Integrative Genomics Establishes GNL3 as a Pleiotropic Hub and Causal Gene for Osteoarthritis

2025-09-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Osteoarthritis (OA) is a leading cause of disability, yet there are no approved disease-modifying therapies (DMOADs) capable of halting its progression. While genome-wide association studies (GWAS) have robustly linked the 3q21locus to OA, the causal effecator gene and its underlying mechanism have remained elusive, hindering translational progress. <bold>Me...

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Literature Corpus work: d656cf69-db56-5417-8479-1924c39366ee
DOI: 10.21203/rs.3.rs-7630649/v1

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