Article
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
Lancet (London, England) - 1 Sept 2012
Zeggini Eleftheria, Panoutsopoulou Kalliope, Southam Lorraine, Rayner Nigel W, Day-Williams Aaron G, Lopes Margarida C, Boraska Vesna, Esko Tonu, Evangelou Evangelos, Hoffman Albert, Houwing-Duistermaat Jeanine J, Ingvarsson Thorvaldur, Jonsdottir Ingileif, Jonnson Helgi, Kerkhof Hanneke J, Kloppenburg Margreet, Bos Steffan D, Mangino Massimo, Metrustry Sarah, Slagboom P Eline, Thorleifsson Gudmar, Raine Emma V A, Ratnayake Madhushika, Ricketts Michelle, Beazley Claude, Blackburn Hannah, Bumpstead Suzannah, Elliott Katherine S, Hunt Sarah E, Potter Simon C, Shin So-Youn, Yadav Vijay K, Zhai Guangju, Sherburn Kate, Dixon Kate, Arden Elizabeth, Aslam Nadim, Battley Phillippa-kate, Carluke Ian, Doherty Sally, Gordon Andrew, Joseph John, Keen Richard, Koller Nicola C, Mitchell Sheryl, O'Neill Fiona, Paling Ellen, Reed Mike R, Rivadeneira Fernando, Swift Diane, Walker Kirsten, Watkins Bridget, Wheeler Maggie, Birrell Fraser, Ioannidis John P A, Meulenbelt Ingrid, Metspalu Andres, Rai Ashok, Salter Donald, Stefansson Kari, Stykarsdottir Unnur, Uitterlinden André G, van Meurs Joyce B J, Chapman Kay, Deloukas Panos, Ollier William E R, Wallis Gillian A, Arden Nigel, Carr Andrew, Doherty Michael, McCaskie Andrew, Willkinson J Mark, Ralston Stuart H, Valdes Ana M, Spector Tim D, Loughlin John
Abstract excerpt
BACKGROUND: Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Osteoarthritis has a strong genetic component but the success of previous genetic studies has been restricted due to insufficient sample sizes and phenotype...
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