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Integrating Single-cell Analysis, Spatial Transcriptomics, Mendelian Randomisation And Machine Learning Frameworks To Identify TNFAIP6 and CHI3L2 As Diagnostic Biomarkers For Osteoarthritis

2025-09-23

Abstract excerpt

<title>Abstract</title> <p>Background Osteoarthritis (OA) is a highly disabling degenerative joint disease, characterized pathologically by a progressive disruption of joint homeostasis. This manifests primarily as degradation of the cartilage extracellular matrix, dysregulation of chondrocyte phenotypes, and osteophyte formation. Clinically, patients commonly present with joint pain and swelling, stiffness, rest...

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Literature Corpus work: 774c33f0-9e4b-57df-99e8-201c1147ee90
DOI: 10.21203/rs.3.rs-7473624/v1

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