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Article

Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis.

Human genomics - 16 Feb 2026

Qu Tianhao, Zhong Yan, Zhou Yonghuan, Liu Lin, Ye Zheng

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a leading cause of disability, yet there are no approved disease-modifying therapies (DMOADs) capable of halting its progression. While genome-wide association studies (GWAS) have robustly linked the 3q21 locus to OA, the causal effector gene and its underlying mechanism have remained elusive, hindering translational progress. METHODS: We implemented a multi-tiered, systematic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41699659
DOI: 10.1186/s40246-026-00920-3
PMCID: PMC13014845

Genes

GNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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