Article

Integrative Multi-Omics Analysis Identifies GZMK as a Causal and Druggable Target in Knee Osteoarthritis

2025-07-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide and causing significant pain and disability, particularly in older adults. It is characterized by articular cartilage degradation, synovial inflammation, and subchondral bone remodeling. <bold>Methods:</bold> This study elucidated the molecular mechanisms driving OA pathogenesis using...

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Literature Corpus work: 5c1398a5-86de-5def-a6ea-420b06953c4a
DOI: 10.21203/rs.3.rs-6976599/v1

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