Article

Phenotype-resolved cis-eQTL Mendelian Randomization and Colocalization Prioritize MAPK3 and UQCC1 in Two Selected Osteoarthritis Candidate Regions

2026-08-03

Abstract excerpt

<title>Abstract</title> <p>Background Osteoarthritis (OA) is a major cause of chronic pain and disability, yet no approved therapy modifies disease progression. Human genetic evidence can improve therapeutic target selection, but OA genome-wide association studies often identify loci without resolving the causal gene or direction of effect. We therefore evaluated genes within two OA-associated regions on chromos...

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Literature Corpus work: 59ff9eed-2af4-5ce6-9fa9-dcce00b1643a
DOI: 10.21203/rs.3.rs-10422413/v1

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