Article

The non-catalytic ε DNA polymerase subunit is an NPF motif recognition protein

2025-03-17

Abstract excerpt

Short linear motifs (SLiMs) in disordered protein regions direct numerous protein–protein interactions, yet most remain uncharacterized. The Asn-Pro-Phe (NPF) motif is a well-known EH-domain ligand implicated in endocytosis, but here we reveal that the non-catalytic subunit of human DNA polymerase ε (POLE2) also serves as a general NPF-motif receptor. Using a quantitative “native holdup” assay, we find that POLE2...

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Identifiers and source

Literature Corpus work: 9c577f91-bfc5-5256-ae0e-f876509415cb
DOI: 10.1101/2025.03.17.643635

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