Article

Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells

2021-09-07

Abstract excerpt

Abstract Human cells need to cope with the stalling of DNA replication to complete replication of the entire genome to minimize genome instability. They respond to “replication stress” by activating the conserved ATR-Claspin-Chk1 replication checkpoint pathway. The stalled replication fork is detected and stabilized by the checkpoint proteins to prevent disintegration of the replication fork, to remove the lesion...

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Identifiers and source

Literature Corpus work: 7a6f2efe-f397-53e7-90bc-c30d18da1824
DOI: 10.1007/s42764-021-00049-8

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