Article

Comparative analysis of single-stranded and non-canonical DNA formation in human and other ape cells with telomere-to-telomere genomes

2025-11-04

Abstract excerpt

<h4>Summary</h4> Non-canonical (non-B) DNA secondary structures, e.g., G-quadruplexes and triplex DNA, are mutation hotspots and genome regulators contributing to disease and evolution. Yet they remain uncharacterized in complete genomes in vivo . Here we exploited the fact that many non-B DNA structures form single-stranded DNA (ssDNA). Using permanganate/S1 footprinting across 14 cell lines, we generated ssDNA...

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Literature Corpus work: c75630cf-403b-5e83-a565-866a20cbff2a
DOI: 10.1101/2025.11.03.686349

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