PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.

Abstract excerpt

The transcriptional cofactor PC4 is an ancient single-strand DNA (ssDNA)-binding protein that has a homologue in bacteriophage T5 where it is likely the elusive replicative ssDNA-binding protein. We hypothesize that human PC4 has retained functions in ssDNA binding to stabilize replication forks and prevent genome instability in mammalian cells. Here we demonstrate that PC4 is recruited to hydroxyurea...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Breaks, Double-Stranded
• Share to DNA Damage
• Share to DNA Repair