Article
The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
2020-08-04
Abstract excerpt
The dysfunction of the cellular endolysosomal pathway, such as in lysosomal storage diseases, can cause severe musculoskeletal disorders. However, how endolysosomal dysfunction causes musculoskeletal abnormalities remains poorly understood, limiting therapeutic options. Here, we report that CHMP5, a member of the endosomal sorting complex required for transport (ESCRT)-III protein family, is essential to maintain...
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Identifiers and source
- Literature Corpus work
- d5f7d618-1621-56f9-8b22-56d4fb77e55f
- DOI
- 10.1101/2020.08.03.233874