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Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

24 Jan 2024

Abstract excerpt

Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes of SSPC senescence remain unclear. In this study, we revealed that macrophages in calluses secrete prosenescent factors, including grancalcin (GCA), during aging, which triggers SSPC senescence and impairs fracture healing. Local injection of human rGCA in young mice induced SSPC...

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PMID: 38267422
DOI: 10.1038/s41413-023-00309-1

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