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Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation

5 Jul 2023

Abstract excerpt

Abstract A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintenance and remodeling of the adult skeleton. However, the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be determined. Here, we established models of premature aging by conditional depletion ofZmpste24(Z24)...

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PMID: 37407584
DOI: 10.1038/s41413-023-00269-6

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