Article

The molecular and cellular interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during osteoclastogenesis

2025-03-31

Abstract excerpt

Bone-resorbing osteoclasts (OCLs) are large, multi-nucleated cells that are formed through well-regulated differentiation and cell fusion of monocyte-macrophage precursors. Disruption of OCL-mediated bone resorption perturbs bone formation, remodeling, and homeostasis that, in turn, can lead to severe illnesses, such as autosomal recessive osteopetrosis (ARO). Mutations in the intracellular trafficking-associated...

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Literature Corpus work: 28510cf7-2f13-5a8a-b743-a83bc63dbe9c
DOI: 10.1101/2025.03.31.646258

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