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Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle

1 Jan 2025

Abstract excerpt

Osteosarcopenia the concurrent deterioration of bone (osteoporosis) and muscle (sarcopenia) represents a critical yet understudied geriatric syndrome that synergistically amplifies frailty, fractures, and loss of independence in aging populations. This dual pathology imposes a staggering socioeconomic burden through increased disability, prolonged hospitalization, and elevated mortality. Despite its clinical...

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PMID: 40540718
DOI: 10.14336/ad.2025.0370

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