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Article

Novel therapeutic interventions for pseudoachondroplasia.

Bone - 1 Sept 2017

Posey Karen L, Hecht Jacqueline T

Abstract excerpt

Pseudoachondroplasia (PSACH), a severe short-limbed dwarfing condition, is associated with life-long joint pain and early onset osteoarthritis. PSACH is caused by mutations in cartilage oligomeric matrix protein (COMP), a pentameric matricellular protein expressed primarily in cartilage and other musculoskeletal tissues. Mutations in COMP diminish calcium binding and as a result perturb protein folding and export...

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Identifiers

PMID: 28336490
DOI: 10.1016/j.bone.2017.03.045
PMCID: PMC6168010

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Novel therapeutic interventions for pseudoachondroplasia.PMID 28336490Read ↗

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Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration.Semantic proximity Read ↗

CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia.Semantic proximity Read ↗

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Semantic proximity Read ↗

Mutant cartilage oligomeric matrix protein (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis.Semantic proximity Read ↗

Pseudoachondroplasia/COMP — translating from the bench to the bedsideSemantic proximity Read ↗

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.Semantic proximity Read ↗

An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype.Semantic proximity Read ↗

Cartilage oligomeric matrix protein: COMPopathies and beyond.Semantic proximity Read ↗

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