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Article

"Bone-SASP" in Skeletal Aging.

Calcified tissue international - 1 Jul 2023

Fang Ching-Lien, Liu Bin, Wan Mei

Abstract excerpt

Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic...

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Identifiers

PMID: 37256358
DOI: 10.1007/s00223-023-01100-4
PMCID: PMC10230496

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