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Article

Schizophrenia is associated with altered DNA methylation variance.

Molecular psychiatry - 1 Apr 2025

Kiltschewskij Dylan J, Reay William R, Cairns Murray J

Abstract excerpt

Varying combinations of genetic and environmental risk factors are thought to underpin phenotypic heterogeneity between individuals in psychiatric conditions such as schizophrenia. While epigenome-wide association studies in schizophrenia have identified extensive alteration of mean DNA methylation levels, less is known about the location and impact of DNA methylation variance, which could contribute to...

Read the complete abstract on PubMed

Topics

Humans
DNA Methylation
Schizophrenia
Male
Female
Adult
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Epigenesis, Genetic

Brain

Cohort Studies

Middle Aged

Genetic Predisposition to Disease

Psychotic Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 39271751
DOI: 10.1038/s41380-024-02749-5
PMCID: PMC11919772

Provenance

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