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Article

Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function

12 Feb 2020

Abstract excerpt

Importance: Schizophrenia is a severe mental disorder in which epigenetic mechanisms may contribute to illness risk. Epigenetic profiles can be derived from blood cells, but to our knowledge, it is unknown whether these predict established brain alterations associated with schizophrenia. Objective: To identify an epigenetic signature (quantified as polymethylation score [PMS]) of schizophrenia using machine...

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PMID: 32049268
DOI: 10.1001/jamapsychiatry.2019.4792

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