Article
Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study.
JAMA psychiatry - 1 May 2016
Montano Carolina, Taub Margaret A, Jaffe Andrew, Briem Eirikur, Feinberg Jason I, Trygvadottir Rakel, Idrizi Adrian, Runarsson Arni, Berndsen Birna, Gur Ruben C, Moore Tyler M, Perry Rodney T, Fugman Doug, Sabunciyan Sarven, Yolken Robert H, Hyde Thomas M, Kleinman Joel E, Sobell Janet L, Pato Carlos N, Pato Michele T, Go Rodney C, Nimgaonkar Vishwajit, Weinberger Daniel R, Braff David, Gur Raquel E, Fallin Margaret Daniele, Feinberg Andrew P
Abstract excerpt
IMPORTANCE: DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. OBJECTIVE: To scan genome-wide DNA methylation data to identify differentially methylated CpGs between SZ cases and controls. DESIGN, SETTING, AND PARTICIPANTS: Epigenome-wide association study begun in 2008 using DNA methylation levels of 456 513 CpG loci...
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