Article
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders.
Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2022
Zhou Jiyun, Chen Qiang, Braun Patricia R, Perzel Mandell Kira A, Jaffe Andrew E, Tan Hao Yang, Hyde Thomas M, Kleinman Joel E, Potash James B, Shinozaki Gen, Weinberger Daniel R, Han Shizhong
Abstract excerpt
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci (mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to extensive linkage disequilibrium (LD) of the genome, it is challenging to identify causal genetic variations that drive DNAm levels by population-based genetic association studies. This limits the utility of mQTLs for fine-mapping risk...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.