Article
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.
Schizophrenia bulletin - 1 Jul 2016
van den Oord Edwin J C G, Clark Shaunna L, Xie Lin Ying, Shabalin Andrey A, Dozmorov Mikhail G, Kumar Gaurav, Vladimirov Vladimir I, Magnusson Patrik K E, Aberg Karolina A
Abstract excerpt
Mutated CpG sites (CpG-SNPs) are potential hotspots for human diseases because in addition to the sequence variation they may show individual differences in DNA methylation. We performed methylome-wide association studies (MWAS) to test whether methylation differences at those sites were associated with schizophrenia. We assayed all common CpG-SNPs with methyl-CpG binding domain protein-enriched genome sequencing...
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