Article

Striatal spinophilin enhances D2R interaction with cytosolic proteins to mediate persistent D2R agonist-induced locomotor suppression

2025-09-15

Abstract excerpt

<h4>SUMMARY</h4> Loss of dopamine neurons in Parkinson disease (PD) leads to motor deficits. Dopamine D2 receptor (D2R) agonists treat PD-associated motor deficits by acting on postsynaptic receptors located within the striatum that have been upregulated due dopamine loss. However, mechanisms that contribute to increased D2R activity in PD to enhance D2R function are poorly described. Spinophilin is a protein pho...

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Literature Corpus work: d5ba5678-6b64-5cb4-aacb-67e0eac33ecf
DOI: 10.1101/2025.09.09.675136

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