Article
A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.
Nature communications - 1 Jan 2013
Rickhag Mattias, Hansen Freja Herborg, Sørensen Gunnar, Strandfelt Kristine Nørgaard, Andresen Bjørn, Gotfryd Kamil, Madsen Kenneth L, Vestergaard-Klewe Ib, Ammendrup-Johnsen Ina, Eriksen Jacob, Newman Amy H, Füchtbauer Ernst-Martin, Gomeza Jesus, Woldbye David P D, Wörtwein Gitta, Gether Ulrik
Abstract excerpt
The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal nerve terminals remain poorly understood. The dopamine transporters contain a C-terminal PDZ (PSD-95/Discs-large/ZO-1) domain-binding sequence believed to bind synaptic scaffolding proteins, but its functional significance is uncertain. Here we demonstrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.