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Article

Dynamic control of the dopamine transporter in neurotransmission and homeostasis

5 Mar 2021

Abstract excerpt

The dopamine transporter (DAT) transports extracellular dopamine into the intracellular space contributing to the regulation of dopamine neurotransmission. A reduction of DAT density is implicated in Parkinson's disease (PD) by neuroimaging; dopamine turnover is dopamine turnover is elevated in early symptomatic PD and in presymptomatic individuals with monogenic mutations causal for parkinsonism. As an integral...

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PMID: 33674612
DOI: 10.1038/s41531-021-00161-2

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