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Article

In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2R1441G mutant mouse model of Parkinson's disease.

Brain and behavior - 1 Feb 2023

Ho Philip Wing-Lok, Li Lingfei, Liu Hui-Fang, Choi Zoe Yuen-Kiu, Chang Eunice Eun Seo, Pang Shirley Yin-Yu, Malki Yasine, Leung Chi-Ting, Kung Michelle Hiu-Wai, Ramsden David Boyer, Ho Shu-Leong

Abstract excerpt

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain. DA uptake activity of DA uptake transporter (DAT) affects synaptic plasticity and motor and non-motor behavior. Synaptogyrin-3 (SYNGR3) is part of the synaptogyrin family,...

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Identifiers

PMID: 36624932
DOI: 10.1002/brb3.2886
PMCID: PMC9927849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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