Article

Langerhans cells immunocompetency is critical for IDO1-dependent ability to induce tolerogenic T cells

2019-12-21

Abstract excerpt

Human epidermal Langerhans cells (LCs) can coordinate both immunogenic and tolerogenic immune responses, creating an attractive opportunity for immunomodulation strategies. To investigate transcriptional determinants of human primary LC tolerance we applied single cells RNA-sequencing combined with transcriptional network modelling and functional analysis. Unsupervised clustering of single cell transcriptomes reve...

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Literature Corpus work: d5b4c22e-901a-52f3-b153-1b1609490599
DOI: 10.1101/2019.12.20.884130

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