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Article

Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology

16 Dec 2022

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a potentially fatal neoplasm characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase (MAPK) pathway activation. LCH cells may trigger destructive pathology yet remain in a precarious state finely balanced between apoptosis and survival, supported by a unique inflammatory milieu. The interactions that maintain this...

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PMID: 36525505
DOI: 10.1126/sciimmunol.add3330

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