Article

TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity

2021-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed mathematical modelling of gene regulatory networks identified by single cell RNA sequencing of LCs exposed to TNF, a key pro-inflammatory signal produ...

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Literature Corpus work: c095b288-8d63-5ac6-82c9-b633894cb2e7
DOI: 10.1101/2021.02.07.430111

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