Article
Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions.
Journal of leukocyte biology - 1 Jul 2008
Santegoets Saskia J A M, Gibbs Susan, Kroeze Kim, van de Ven Rieneke, Scheper Rik J, Borrebaeck Carl A, de Gruijl Tanja D, Lindstedt Malin
Abstract excerpt
In human skin, two main populations of dendritic cells (DC) can be discriminated: dermal DC (DDC) and epidermal Langerhans cells (LC). Although extensively studied, most of the knowledge about DDC and LC phenotype and function is obtained from studying DDC and LC cultured in vitro or DDC and LC migrated from skin explants. These studies have left the exact relationship between steady-state human LC and DDC...
Topics
- Antigens, CD1
- Cell Differentiation
- Cell Movement
- Chemokines
- Cluster Analysis
- Flow Cytometry
- Gene Expression Profiling
- Gene Expression Regulation
- Humans
- Immune Tolerance
- Langerhans Cells
- Phenotype
- Receptors, Immunologic