In vitro differentiation and phenotypic profiling of Langerhans cell subsets derived from human peripheral blood monocytes.

Abstract excerpt

Langerhans cells (LCs) are primary immune sentinels at barrier surfaces, acting as the first line of defence against foreign pathogens. However, their low abundance within the human epidermis severely limits their availability for functional and mechanistic studies. To address this challenge, we sought to provide a versatile experimental framework for generating, identifying, and characterizing distinct subsets...

Topics

• Humans
• Langerhans Cells
• Cell Differentiation
• Monocytes
• Cells, Cultured
• Phenotype