Article

Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells

2019-02-05

Abstract excerpt

Langerhans cells (LCs) in the epidermis present MHC I and MHC II-restricted antigens thereby priming either CD8 or CD4 T cell immune responses. The genomic programs and transcription factors regulating antigen presentation in LCs remain to be elucidated. We show human LCs are highly efficient in MHC I-antigen cross-presentation but lack the transcription factor IRF8 that is critical in dendritic cells. LC migratio...

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Literature Corpus work: d46b0fee-acc4-59fa-b10b-f30330dbb3f9
DOI: 10.1101/541383

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