Article

Upgraded molecular models of the human KCNQ1 potassium channel

2019-05-24

Abstract excerpt

The voltage-gated potassium channel KCNQ1 (K V 7.1) assembles with the KCNE1 accessory protein to generate the slow delayed rectifier current, I KS , which is critical for membrane repolarization as part of the cardiac action potential. Loss-of-function (LOF) mutations in KCNQ1 are the most common cause of congenital long QT syndrome (LQTS), type 1 LQTS, an inherited genetic predisposition to cardiac arrhythmia...

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Literature Corpus work: f6f09cfd-fa24-5d35-8f25-14e6dd9b982b
DOI: 10.1101/648634

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