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Article

Long QT syndrome-associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel.

The Journal of physiology - 1 Sept 2023

McCormick Liam, Wadmore Kirsty, Milburn Amy, Gupta Nitika, Morris Rachael, Held Marie, Prakash Ohm, Carr Joseph, Barrett-Jolley Richard, Dart Caroline, Helassa Nordine

Abstract excerpt

Calmodulin (CaM) is a highly conserved mediator of calcium (Ca2+ )-dependent signalling and modulates various cardiac ion channels. Genotyping has revealed several CaM mutations associated with long QT syndrome (LQTS). LQTS patients display prolonged ventricular recovery times (QT interval), increasing their risk of incurring life-threatening arrhythmic events. Loss-of-function mutations to Kv7.1 (which drives...

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Identifiers

PMID: 37428651
DOI: 10.1113/JP284994
PMCID: PMC10952621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Long QT syndrome-associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel.PMID 37428651Read ↗

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