Article

Inhibition of microglial GBA hampers the microglia-mediated anti-oxidant and protective response in neurons

2021-01-20

Abstract excerpt

Homozygotic mutations in the GBA gene cause Gaucher’s disease, moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson’s disease. In homozygosis, these mutations impair the activity of β-glucocerebrosidase, the enzyme encoded by GBA, and generate a lysosomal disorder in macrophages, which changes morphology towards an engorged phenotype, co...

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Literature Corpus work: ec2315be-188e-57ac-8d23-f6a58698d17b
DOI: 10.1101/2021.01.20.427380

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