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Article

PCSK9 genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations.

European journal of preventive cardiology - 3 Jun 2024

Holmes Michael V, Kartsonaki Christiana, Boxall Ruth, Lin Kuang, Reeve Nicola, Yu Canqing, Lv Jun, Bennett Derrick A, Hill Michael R, Yang Ling, Chen Yiping, Du Huaidong, Turnbull Iain, Collins Rory, Clarke Robert J, Tobin Martin D, Li Liming, Millwood Iona Y, Chen Zhengming, Walters Robin G

Abstract excerpt

AIMS: Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large biobanks can help to identify unexpected effects of PCSK9 inhibition. METHODS AND RESULTS: In the prospective China Kadoorie Biobank, we constructed a genetic score using three...

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Identifiers

PMID: 38198221
DOI: 10.1093/eurjpc/zwae009
PMCID: PMC11144468

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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