GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.

doi:10.1038/s41431-023-01485-8

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GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.

European journal of human genetics : EJHG - 1 Feb 2024

Senftleber Ninna Karsbæk, Andersen Mette K, Jørsboe Emil, Stæger Frederik Filip, Nøhr Anne Krogh, Garcia-Erill Genis, Meisner Jonas, Santander Cindy G, Balboa Renzo F, Gilly Arthur, Bjerregaard Peter, Larsen Christina Viskum Lytken, Grarup Niels, Jørgensen Marit Eika, Zeggini Eleftheria, Moltke Ida, Hansen Torben, Albrechtsen Anders

Abstract excerpt

Perturbation of lipid homoeostasis is a major risk factor for cardiovascular disease (CVD), the leading cause of death worldwide. We aimed to identify genetic variants affecting lipid levels, and thereby risk of CVD, in Greenlanders. Genome-wide association studies (GWAS) of six blood lipids, triglycerides, LDL-cholesterol, HDL-cholesterol, total cholesterol, as well as apolipoproteins A1 and B, were performed in...

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PMID: 37903942
DOI: 10.1038/s41431-023-01485-8
PMCID: PMC10853193

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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