Article

<i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodelling

2025-02-27

Abstract excerpt

<h4>Background and aims</h4> Circulating PCSK9 is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascular disease (CVD) risk, while gain-of-function variants correlate with elevated LDL-C concentrations and increased CVD risk. This study investigated whether genetically d...

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Literature Corpus work: 38e26824-434d-58ec-94e0-311f5f2af475
DOI: 10.1101/2025.02.25.25322905

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