Article
Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese.
Human molecular genetics - 15 Sept 2016
Lu Xiangfeng, Li Jun, Li Huaixing, Chen Yang, Wang Laiyuan, He Meian, Wang Yiqin, Sun Liang, Hu Yao, Huang Jianfeng, Wang Feijie, Liu Xuezhen, Chen Shufeng, Yu Kuai, Yang Xueli, Mo Zengnan, Lin Xu, Wu Tangchun, Gu Dongfeng
Abstract excerpt
Previously identified common variants explain only a small fraction of the trait heritability and at most loci the identities of the underlying causal genes and their functional variants still remain unknown. To identify the low-frequency and rare coding variants that influence lipid levels, we conducted a meta-analysis of exome-wide association studies in 14,473 Chinese subjects, followed by a joint analysis...
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