Article

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in <i>PCSK9</i>

2018-05-25

Abstract excerpt

<h4>Background</h4> We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. <h4>Methods</h4> Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Fourteen randomized placebo controlled PCSK9 inhibitor trials were in...

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Literature Corpus work: 3dc7a058-c832-5bf3-b6f6-a43a8627f37c
DOI: 10.1101/329052

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