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Article

Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit.

American journal of human genetics - 4 Dec 2025

Stinson Sara E, Balboa Renzo F, Andersen Mette K, Stæger Frederik F, He Shixu, Baun Thuesen Anne Cathrine, Lin Long, Jørsboe Emil, Bjerregaard Peter, Larsen Christina V L, Grarup Niels, Jørgensen Marit E, Moltke Ida, Albrechtsen Anders, Hansen Torben

Abstract excerpt

Circulating proteins play essential roles in complex diseases, yet protein quantitative trait locus (pQTL) studies in non-European, isolated populations remain limited. We analyzed genotypes and plasma proteomics data (Olink Target 96 Inflammation and Cardiovascular II panels) from 3,707 Greenlandic individuals (mean age: 47.9 years; 54.5% female), using linear mixed models to account for relatedness and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41232531
DOI: 10.1016/j.ajhg.2025.10.013
PMCID: PMC12808951

Genes

CPT1A
HNF1A
LDLR
PCSK9
TBC1D4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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