Article

<i>PCSK9</i>genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations

2023-08-16

Abstract excerpt

<h4>Background</h4> Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large prospective biobanks can help to identify unexpected effects of PCSK9 inhibition. <h4>Methods</h4> The prospective China Kadoorie Biobank genotyped >100,000 participan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a4257ce-2d64-5f93-9c12-f8c63d2cc37b
DOI: 10.1101/2023.08.15.23294117

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>PCSK9</i>genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populationsDOI 10.1101/2023.08.15.23294117Read

PCSK9 genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations.Semantic proximity Read

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in <i>PCSK9</i>Semantic proximity Read

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.Semantic proximity Read

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.Semantic proximity Read

<i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodellingSemantic proximity Read

Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels and Its Impact on Atherosclerotic Vascular Disease Phenotypes.Semantic proximity Read

Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke.Semantic proximity Read

Association of PCSK9 Variants With the Risk of Atherosclerotic Cardiovascular Disease and Variable Responses to PCSK9 Inhibitor TherapySemantic proximity Read

Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors.Semantic proximity Read

PCSK9 and Lipid Metabolism: Genetic Variants, Current Therapies, and Cardiovascular Outcomes.Semantic proximity Read

Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart DiseaseSemantic proximity Read

Large-scale phenome-wide association study of <i>PCSK9</i> loss-of-function variants demonstrates protection against ischemic strokeSemantic proximity Read