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Article

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.

Genome research - 1 Mar 2016

Diao Yarui, Li Bin, Meng Zhipeng, Jung Inkyung, Lee Ah Young, Dixon Jesse, Maliskova Lenka, Guan Kun-Liang, Shen Yin, Ren Bing

Abstract excerpt

With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA. Millions of regulatory sequences have been predicted in the human genome through analysis of DNA methylation, chromatin modification, hypersensitivity to nucleases, and transcription factor binding, but few have been shown to regulate transcription in their native contexts. We have developed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26813977
DOI: 10.1101/gr.197152.115
PMCID: PMC4772021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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